An early study ‘infuses hope’ back into attempts to use immunotherapy to treat brain cancer

first_img Please enter a valid email address. By Andrew Joseph Feb. 11, 2019 Reprints By decoding flickering brain signals, scientists envision a new way to detect consciousness Giving patients with lethal brain tumors a powerful new form of cancer treatment before they underwent surgery helped them live longer on average than patients who started the drugs after surgery, researchers reported in a study published Monday.While the study was small, and while most patients still died by the end of the study period, researchers said the results suggested timing could be an important factor when trying to treat glioblastoma, or GBM, with immunotherapies, which are designed to unleash the immune system on cancer cells. Previous attempts to use immunotherapies to help GBM patients have failed to yield broad clinical benefits, and any positive results catch attention with a cancer as formidable as GBM, which has a median survival time of just a few years.“We’ve at least found a window,” said Robert Prins, a tumor immunologist at the UCLA Jonsson Comprehensive Cancer Center and a senior author of the paper. “Before we just hadn’t seen anything. Now, I think we’re seeing a signal.”advertisement Researchers aren’t sure why the patients who received pembrolizumab before surgery lived longer, but it’s possible that providing the drug and surgery in that order amounted to a one-two punch. Perhaps, experts said, the drug needs to be activated by being exposed to proteins on the outside of the tumor cells called antigens — which act as little flags identifying invaders the immune system should attack. Then, when the tumor was removed, the curtain of immunosuppression that the tumor holds up was dropped, so the drug could swarm the cells the surgery left behind.When researchers looked at what was going on inside the immune and tumor cells, they found that in patients who received the drug before surgery, immune cells were geared to attack and kill cancer cells, while their cancer cells were slower to copy themselves.But even if these patients lived longer, most of them had still died by the end date of the study. Dr. Hideho Okada, the director of the brain tumor immunotherapy program at University of California, San Francisco, likened GBM to a car with a host of issues — brakes, transmission, the engine, and so on. A PD-1 inhibitor like pembrolizumab is only designed to take care of one of those problems, but the cancer has a bevy of other challenges that need to be addressed if the tumor is to be fully vanquished.“In order to make the car start running again safely, you have to fix each of these problems,” said Okada, who was not involved with the study. “PD-1 is addressing one mechanism, so to build on this preliminary success, we have to plan rational combinations of immunotherapy drugs.” Related: About the Author Reprints A view of the tumor cells after a glioblastoma patient was treated with the checkpoint inhibitor pembrolizumab. Joey Orpilla/UCLA The study focused on 32 patients who had recurrent GBM — people who already had a first round of treatment (GBM is initially treated with surgery, radiation, and a chemotherapy called temozolomide) and whose cancers started growing again. For the study, half of them started on a checkpoint inhibitor before they had surgery to remove as much of the regrowing tumor as possible, and half waited to begin the drug until after the surgery.Patients in the first group had a median survival of 417 days, while patients in the second group had a median survival of 228 days. Patients who received the drug before surgery also went longer before the tumor started progressing again.The research was conducted at seven centers from October 2016 to September 2017. By July 2018, when the researchers stopped tracking them for the study, 12 of the patients in the later-start group had died, and nine of the earlier-start group had died.By awakening immune cells and pulling down the defenses of cancer cells, immunotherapies have enabled remarkable recoveries for some patients with some cancers. But brain tumors have proved among the hardest cancers to target. In December, two research teams reported they could rally a promising immune response in GBM patients with another type of immunotherapy called a neoantigen vaccine, but that it didn’t lead to improved outcomes for patients. Leave this field empty if you’re human: Brain tumors are particularly difficult to treat for a number of reasons. It’s hard for medicines in general to penetrate into the brain. More specifically, brain tumors don’t have as many genetic vulnerabilities for cancer therapies to pounce on as other tumors. They are also able to tamp down immune activity — making them so-called immunologically cold cancers.In this study, researchers tested a checkpoint inhibitor. Checkpoints are one of cancer’s ways of stopping immune cells from demolishing tumor cells, so inhibitors work by interfering with those checkpoints. The study used pembrolizumab, which blocks the PD-1 checkpoint and is approved for some forms of cancer as Keytruda. (Merck, which makes Keytruda, provided the drug for the study.)Researchers initially designed the study just as a scientific survey to compare what happened to the immune system and tumor in the different patient groups; they weren’t expecting to uncover an apparent clinical benefit when it came to the timing of the treatments.“The original idea was really to understand what PD-1 blockade does to the tumor microenvironment, what it does to the immune response to the tumor in the brain,” said Prins, who is also affiliated with Parker Institute for Cancer Immunotherapy. HealthAn early study ‘infuses hope’ back into attempts to use immunotherapy to treat brain cancer “It’s exciting because up to now, immunotherapies looked like they were going down the road for everything else — ‘Oh, they work in peripheral tumors, but not in the brain,’” said Dr. Frederick Lang, the chair of neurosurgery at MD Anderson Cancer Center, who was not involved in the research. “This study really infuses hope back into the field, that these checkpoint inhibitors may be effective if we use them in the correct way,” he added, referring to the type of immunotherapy used in the trial.advertisementcenter_img Not if but when: After a diagnosis of brain cancer, a young dad and his family grapple with the uncertain time he has left Newsletters Sign up for Morning Rounds Your daily dose of news in health and medicine. @DrewQJoseph Privacy Policy Related: Andrew Joseph General Assignment Reporter Andrew covers a range of topics, from addiction to public health to genetics. [email protected] Outside experts echoed Prins, noting that this was a randomized trial — patients were divided into different treatment groups to compare the results — which lends more weight to the findings. While they cautioned that many initially exciting study results do not hold up in larger investigations, they said the study, which was published in the journal Nature Medicine, laid the groundwork for research that would combine different immune-boosting strategies at this point in a patient’s disease. Tags cancerdrug developmentresearchlast_img read more

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US Olympic fencer Ibtihaj Muhammad comfortable speaking out

first_imgIn this March 8, 2016, file photo, Fencer Ibtihaj Muhammad poses for photos at the 2016 Olympic Team USA media summit in Beverly Hills, Calif. Muhammad is set to become the first American to compete in the Olympics wearing a hijab. (AP Photo/Jae C. Hong, File)NEW YORK (AP) _ First lady Michelle Obama wrapped up her speech to dozens of U.S. athletes to mark 100 days before the Rio Games and immediately headed over to a temporary court set up in the middle of Times Square.There she was greeted by Olympian Ibtihaj Muhammad, the two women sharing a long embrace. Muhammad then gave Mrs. Obama a quick fencing lesson before the first lady and a young girl practiced their technique with foam foils.In the meticulously staged photo op Wednesday was plenty of symbolism, and Muhammad, who is set to become the first American to compete in the Olympics while wearing a hijab, feels comfortable as the face of that message.(Getty Images)This Olympic year is also an election year, one in which Republican front-runner Donald Trump has suggested that Muslims be banned from entering the United States. Amid that backdrop, Muhammad, a 30-year-old New Jersey native, finds herself with many opportunities to speak out.“It’s unfortunate that we’re in this moment, especially during the presidential election, where people feel so comfortable voicing their dislike or the discontent for people of a particular background, a particular race or a particular religion,” she told reporters later. “We as Americans have to fight that, because that goes against the very values that we stand for.“I feel like I’m in this position and I have to use it, and I want to use it well. I don’t want to waste my time as an athlete; I want to reach as many people as I can _ just not with my skills within my sport but also with my voice.”Muhammad, who qualified for Rio in saber, said she found out only a few hours earlier that she’d be fencing with Mrs. Obama. She had met the president before but not the first lady.Mrs. Obama later took part in passing drills with kids and members of the U.S. women’s basketball team.Earlier, with dozens of American athletes from various sports standing behind her, the first lady described herself as a “real, lifelong, die-hard Olympics fan.” She reminisced about growing up on Chicago’s South Side, where the kids would crowd around one neighbor’s TV and “watch for hours.”“Once the games were over, we would all run outside and set up some makeshift hurdle or some balance beam, and we’d try to imitate our heroes,” Mrs. Obama said in announcing a partnership by the U.S. Olympic Committee, NBC and summer sport national governing bodies called “Gold Map” that will encourage youngsters to take up Olympic sports.last_img read more

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2011 Senior Games to face major challenge

first_imgBy Timothy Schafer, The Nelson Daily There are major challenges facing the 2011 Senior Games before it comes to the West Kootenay region, but they are challenges that could see the region prosper, says the president of the Games committee. Pat Metge said with the Waneta Dam expansion project in Trail, all of the construction projects in Castlegar and the stream of tourists that are regularly coming into Nelson, the Games next August will be hard pressed to accommodate 3,500 athletes. The region is going to be very busy, he said, and people coming to the Games are going to go beyond the accommodations of the three cities. “Accommodations up in the Slocan Valley, Nakusp way, there is a great opportunity here. These people will be in our communities for over four days,” he said. “The economic spin-off is great for our area.” The Games does not provide accommodations, food or transportation to the events, said Games vice president Keith Smythe. It will be the largest event the West Kootenay has seen, he said, with 28 events being split between three cities of Nelson, Trail and Castlegar. With a headquarters now being set up in Castlegar, the Games committee has to raise $50,000 in corporate sponsorship to go with the core grant of $85,000 from the Senior Games Society, $112,000 from registration fees for 3,500 registrations, $55,000 in cash from each city and $55,000 of in kind donations. “But we are very positive and we see it as a big challenge and an opportune time to bring our three areas together,” said Smythe. [email protected] Not everyone is happy with the Games There is some ill will towards the Games since the West Kootenay area of Creston and the Creston Valley was left out of the hosting process. Area C director Larry Binks wondered why the town of Creston, the valley and that side of the mountain were ignored. “If they come to me asking for money, I give this push back right away. I’m feeling a little out of sorts the way this is looking,” he said. Creston and the valley were not part of the bid package, said Smythe. “But, with regard to economic benefit, I think there will be total economic benefit to all areas of the West Kootenay because people will be traveling through your communities,” he said. “And there is a limit with regard to accommodations so who knows where people will be staying,” added in Metge. RDCK chair Gary Wright said so far the Creston area has not been asked to front any money for the Games.last_img read more

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Leinster Senior Hurling Final Match Tracker

first_imgThe referee blows the full time whistle….IT’S ALL OVER…….GALWAY ARE THE LEINSTER SENIOR HURLING CHAMPIONS FOR 2017!!!!!!Yellow Card for Greg LallyLee Chin with a free for Wexford…Galway 0-29 Wexford 1-17……Final thirty seconds……Yellow Cards for Owen Moore and Niall BurkeTom Monaghan has all the time in the world and he scores for Galway…..Galway 0-29 Wexford 1-16Shane Maloney scores Galway’s twenty eighth point! They lead Wexford 0-28 to 1-16Cathal Dunbar with a point for Wexford….Galway 0-27 Wexford 1-16Free Galway…Colm Callinan takes it but the ball is cleared by the Wexford backs…Greg Lally comes into the Galway team for Joseph CooneyShane Maloney comes in for Galway…..Joe Canning comes offJoseph Cooney with a great point…..Galway 0-27 Wexford 1-15Conor McDonald with a free and it is now Galway 0-26 Wexford 1-15Yellow Card Joe Canning (We think)Aidan Nolan has a goal chance for Wexford but it goes wideSix minutes left in Croke Park……Wexford Sub – Shane Tomkins comes onJoe Canning gets treatment but is ok to continueTen minutes left in the Leinster Hurling Final….And Niall Burke scores an incredible point…..Galway 0-26 Wexford 1-14 (17)Half Time in the Connacht Senior Ladies Football Final…..Galway 3-7 Mayo 0-4Conor Whelan to Conor Cooney…Another Galway Point…..Galway 0-25 Wexford 1-14Joe Canning with a sideline cut and he send it over the bar! Galway 0-24 Wexford 1-14Conor Whelan is fouled and Galway have a free…..Conor Cooney takes the free and he puts it over the bar….Galway 0-23 Wexford 1-14Conor Cooney with an important point given the recent pressure Galway 0-22 Wexford 1-14Free for Wexford….Conor McDonald scores and now it’s Galway 0-21 Wexford 1-14Into the final twenty minutes….Wexford are buzzing again…Cathal Dunbar comes into the Wexford TeamJack Guiney…..He has a chance…GOAL WEXFORD! They are back in the match….Galway 0-21 Wexford 1-13Lee Chin goes for a score…..Referee goes for Hawk Eye and the point is given….Galway 0-21 Wexford 0-13Galway are going through the gears…Joseph Cooney with an absolutely incredible score…Galway now lead by 0-21 to 0-12.The Galway Supporters are finding their voice…Joe Canning….What a point! Galway 0-20 Wexford 0-12.Padraig Mannion Makes another outstanding Catch and is fouled….Free GalwayOwen Moore comes in for Wexford…Joseph Cooney with another Galway Point….Galway 0-19 Wexford 0-12….Niall Burke with another Galway point…Galway now 0-18 to 0-12 up with Forty Five Minutes Gone in the Leinster Hurling Final….Mairead Seoige has scored ANOTHER Goal for Galway…They now lead 3-6 to 0-4Joe Canning scores another free…Galway 0-17 Wexford 0-12Conor Cooney and this time he scores an excellent point…Galway 0-16 Wexford 0-12Joe Canning takes the 65′ and it sails over the bar…Galway 0-15 Wexford 0-12….At the other end…..Conor Whelan….CLOSE……65′ Galway…..Lee Chin takes the 65’…….It goes over the bar….Galway 0-14 Wexford 0-12The Penalty from Conor McDonald…..SAVED BY CALLINANThe television pictures are showing that it was NOT a penaltyAidan Nolan has a chance…Brilliant save by Colm Callinan….Ball breaks….PENALTY WEXFORDConor Cooney tries for a point but it goes wide……It’s wide…..Galway lead 0-14 to 0-11Conor McDonald has a chance…The umpire calls Hawk Eye….Second Half is underway….David Redmond comes for Wexford for the second half…The Galway team are back out on the pitch for the Leinster Senior Hurling Final….The Attendance today at Croke Park….Galway getting a dream start in the Ladies Connacht Senior Football Final…They lead 2-5 to 0-1Bloody Hell…..Latest Score from the Ladies Connacht Senior Final…. Five Minutes Gone in the First Half….Galway 2-2 Mayo 0-0…Mairead Seoige and Niamh Duggan with the goals….Half Time Score…Galway 0-14 Wexford 0-11The clock reads 40 minutes…..Joe Canning with the free and he does not miss…Galway lead by 0-14 to 0-11 as referee Colm Lyons blows the whistle for Half TimeYellow Card for Jack Guiney of WexfordAidan Harte is hit late and a free for GalwayNiall Burke looked to have scored but the umpire waves it wideFoul on Lee Chin and they have a chance to close the gap to one….Conor McDonald takes it but he misses….Four Minutes of injury time to be played.Joseph Cooney with a great point and Galway now go two points in front…Galway 0-13 Wexford 0-11Lee Chin takes the free but it goes wideYellow Card for Tom Monaghan….Tough call on Monaghan who was only holding his ground…Galway putting the pressure on slightly and John Hanbury wins the free….Joe Canning scores point number five….Galway now in front…Galway 0-12 Wexford 0-11Galway sub – Thomas Monaghan comes in for Jason FlynnNow Conor Cooney scores for Galway….0-11 each with five minutes left in the first half….Wexford’s Willy Devereux now gets on the score sheet and they now lead 0-11 to 0-10.Joe Canning scores the free and the teams are level again…..Galway 0-10 Wexford 0-10Yellow Card James Breen for Wexford…Twenty Five Minutes gone in the game so far….Canning puts it between the post from between his own 65′ and 45’…Teams are level but Aidan Nolan gives Wexford the lead again. Wexford 0-10 Galway 0-9.Free for Galway….Chance for a leveler…Joe Canning will take it…Johnny Coen with the response for Galway….0-9 to 0-8Conor McDonald finds Paul Morris and Morris scores…Wexford 0-9 Galway 0-7Joseph Cooney hots back with a point for Galway and just one point separate the sides…Wexford 0-8 Galway 0-7 after twenty one minutes…Wexford tails are up at the minute…Jack O’Connor scores another point and Wexford now lead by two points….Lee Chin is going to take the free and it goes over the bar…Wexford 0-7 Galway 0-6This is a tight game of inches at this stage…Lee Chin is fouled and Wexford can take the lead…Conor McDonald takes possession and scores from outside the 45’….Teams are level again….0-6 each….Seventeen minutes gone…Padraig Mannion tries one as well but is hooked…..ball goes out for a line ball…Jason Flynn tries one from Half Way but it goes wide…Free Galway…..Joe Canning makes no mistake….Galway lead 0-6 to 0-5…..Anything Galway can do, Wexford respond….Matthew O’Hanlon this time for Wexford….0-5 each after fourteen minutes.Conor Cooney again for Galway with point number four…Galway lead 0-5 to 0-4.Galway back in front with a point from Conor Cooney….Diarmuid O’Keeffe hits back for Wexford…Teams are level again…Galway 0-4 Wexford 0-4McDonald scores and the teams are level…..Galway 0-3 Wexford 0-3…Eleven Minutes gone…..Ref Colm Lyons not popular with Galway supporters at the moment….Free Wexford….Conor McDonald will take it….Small worry for Galway…..Niall Burke gets treatment for a knock but he gets up after a couple of minutes….Conor Cooney picks up a yellow card.Conor McDonald responds with a good point for Wexford…Galway 0-3 Wexford 0-2….Seven minutes gone…Padraic Mannion tries one from half way and it flies over the bar…Galway 0-3 Wexford 0-1Four minutes gone and Paul Morris scores Wexford’s first point….Galway 0-2 Wexford 0-1Galway free after Conor Whelan is fouled…..Joe Canning points and Galway now lead 0-2 to 0-0.Aidan Nolan attempts a shot for Wexford but it goes wide…..Back in Croke Park…..The game is underway and Conor Cooney points for Galway after 30 seconds….Galway 0-1 Wexford 0-0The stage is setIn McHale Park…The All-Ireland winning Galway Under 14 Ladies have arrived….The Parade is underway…Almost time for throw in….The players are out on the pitch and are currently meeting the President of Ireland Michael D Higgins…Wexford Team News……No Changes from the match programme….Kerry have won the Munster Senior Football Final hammering Cork by 1-23 to 0-15It has been confirmed….Cathal Mannion to miss the game…Jason Flynn replaces himKilkenny have won the Leinster Minor Final beating Dublin by 3-15 to 1-17.The Galway team are due out on the pitch at 3.30……Team News….Cathal Mannion may not start the game due to injury and it looks like he will be replaced by Jason FlynnHalf Time in the Munster Senior Football Final – Kerry 0-11 Cork 0-7The Teams as listed in the programme…..Nice view from the Hogan Stand….The Teams were announced on Friday Evening….Galway  made one change from the team that defeated Offaly in Leinster Senior Hurling Championship Semi Final with Joseph Cooney replacing Jason Flynn and Cathal Mannion despite being a major doubt due to ankle injury is fit enough to make the Galway team. Wexford have stuck with the same team that defeated Kilkenny and sharp shooter Conor McDonald has been deemed fit enough to start.Galway (Leinster SHC final v Wexford): Colm Callanan; Adrian Touhy, Daithi Burke, John Hanbury; Padraic Mannion, Gearoid McInerney, Aidan Harte; Johnny Coen, David Burke; Niall Burke, Joe Canning, Joseph Cooney; Conor Whelan, Conor Cooney, Cathal Mannion.Wexford (Leinster SHC v Galway): Mark Fanning; Willie Devereux, Liam Ryan, James Breen; Simon Donohoe, Matthew O’Hanlon, Diarmuid O’Keeffe; Shaun Murphy, Aidan Nolan; Jack O’Connor, Lee Chin, Conor McDonald; Paul Morris, Jack Gibney, Harry Kehoe.All Teams news with be up shortly and why not get involved by going to our Facebook page https://www.facebook.com/GBFMSports/ or text us on 53995 and leave a comment!It’s Galway and Wexford with Galway looking to win their first Leinster Senior Hurling Crown since 2012!Hello and Welcome To Galway Bay FM’s Match Tracker for the Leinster Senior Hurling Final.print WhatsApp Facebook Twitter Email Thanks for reading…Roll on next weekend and the Connacht Senior Football Final between Galway and Roscommon! What a day for Galway Hurling…Leinster Senior Hurling Champions for 2017….Next up is the All-Ireland Senior Hurling Semi-Final….last_img read more

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Nelson Boxers Eberle, Martinez, Raffo sweep bouts

first_img Voted Boxing Club of the Year by the BC Amateur Boxing Association”We are very proud of these great athletes who compete in one of the most demanding sports on earth and are developing into great boxers and great people,” said a Nelson Boxing Club spokesperson.”The amateur team will be working hard over the summer on conditioning goals in order to exceed these accomplishments in 2020.”Nelson Boxing Club hosts Summer CampsThe Nelson Boxing Club is excited to present a mash-up of Parkour and Boxing in the form of Summer Camps for kids ages 7-11 this July and August in collaboration with the Nelson Boxing and Athletics Club.These camps will offer a unique experience for kids and a nice break for parents, combining fitness, fun and learning over five days — July 22nd to 26th, or August 19th to 23rd.Parkour and non-contact boxing instruction, exercises, games and more will all be included! Sessions will run from 9:00am to noon! If you’re interested in signing up, contact Mateus at [email protected] or (250) 265-1577.Online sign up will be available soon, along with a Facebook event and more details, so stay tuned. The Spokane card concludes a very successful season inside the ring for the Nelson Boxing Club.Some of the highlights include: 77 total bouts 4 Tacoma Golden Gloves Champions (Stryder Sutton, Riel Martinez, Leah Eberle, Makalu Babott) 3 Silver Medalists and 1 Bronze at the Canadian Championships in Langford, BC. (Elias Martinez, Leah Eberle, Makalu Babott, Brayden Hellekson) Jimmy Simms Award for Excellence (Samson Berkeley) Junior Boxer of the Year (Elias Martinez)center_img Nelson Boxers won a trio of medals during a recent fight card in Spokane, Washington.Leah Eberle, Riel Martinez and Marino Raffo all won their respective bouts this past weekend in the Lilac City.Eberle, 16, won a very tough, fast paced decision against #6 (USA) ranked Rosalee Ruiz from Walla Walla, WA. Eberle was coming off a silver medal performance at the National Championships and really put all her skills and conditioning to the test against a very talented opponent.Martinez, 13, used his strength and aggressive boxing to earn a decision against Matthew Charlton from Portland, Or. Martinez dug deep to get the win against a very experienced and speedy opponent.Meanwhile, Raffo, 11, won a dominant decision against Alec Grant, Spokane, WA. Raffo’s superior boxing skills and southpaw angles were the difference against the very tough Grant. 1 Alberta Golden Gloves Champion (Brett Adams) 9 BC Provincial Champions (Ryan Lewis, Elias Martinez, Brayden Hellekson, Riel Martinez, Max Berkeley, Leah Eberle, Stryder Sutton, Makalu Babott, Brett Adams) 1 Bronze Medal, 2019 Canada Winter Games, Red Deer, Alberta (Brayden Hellekson)last_img read more

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Jackson & Haywood Businesses Selected for ScaleUp WNC

first_imgMountain BizWorks (MBW) has selected 15 small businesses in the region with strong potential for growth and job creation to take part in the third cohort of their ScaleUp WNC program, which began last Friday. Innovation Brewing, a seven-barrel brewery located in Sylva, and Copper Pot & Wooden Spoon, a Waynesville company that handcrafts seasonally produced jams, pickles, and artisan foods, are participating. The initiative, made possible with financing from the U.S. Small Business Administration, aims to provide these businesses and fellow WNC entrepreneurs with intensive growth strategy development, mentorship, access-to-capital support, and a rich network of peer business owners.ScaleUp WNC launched in 2015, and funding will allow the nonprofit to continue hosting two cohorts annually through 2019. MBW says the end result of the high-impact initiative will be a diverse and distinguished group of entrepreneurs able to drive innovation and economic development across WNC for a long time to come. Thirty companies completed the program in 2015. To date, one-third of those alumni have already secured growth capital, and many more have met other major milestones—a testament to ScaleUp WNC’s design and curriculum.“We’ve been pleased with the outcomes of the program to date,” shares Matt Raker, director of community investments and impact at MBW. “It has provided and will continue to provide much-needed support to area ventures that are primed for expansion, so that they can experience sustained success while creating jobs and making a positive impact on our local economy.”The complete list of 2016 ScaleUp WNC participating businesses follows: Black Mountain Ciderworks (Black Mountain), Blue Ridge Energy Works (Boone), Brian Boggs Chairmakers (Asheville), Copper Pot & Wooden Spoon (Waynesville), East Fork Pottery (Marshall), Innovation Brewing (Sylva), Kudzu Brands (Black Mountain), Medea’s Espresso & Juice Bar (Arden), No Evil Foods (Asheville), Organic Planet Cleaning (Asheville), Outfitter Bicycle Tours (Hendersonville), Pisgah Pest Control (Brevard), Port City Amplification (Swannanoa), Printville (Asheville), and Still Point Wellness (Asheville).“In year one, we helped businesses scale from Boone to Bryson City, and we’re excited to work with companies from seven WNC counties this spring,” says Raker. “We’re also pleased that two-thirds of the businesses are women-owned, minority-owned, or based in a rural community, as our mission is to create economic opportunity for all.”MBW has received more than 45 applications for the 2016 program. Cohort 3 began Friday, March 4, and runs through mid-May. The following cohort will run from June through September. Applications are continuing to be accepted for Cohort 4 and are due by April 17.last_img read more

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SCC to host Small Business Summit on Dec. 4

first_imgSouthwestern Community College’s Small Business Center will be hosting a free Small Business Summit along with other area businesses including Entegra Bank, Lady Bizness, Western Women’s Business Center and Stanberry Insurance, from 9 a.m. – 5 p.m. on Monday, Dec. 4, in the Burrell Building on SCC’s Jackson Campus.“This truly is the most comprehensive event we’ve offered in my tenure here at the Small Business Center,” said Tiffany Henry, SCC’s Small Business Center director. “Not only do we have the best line-up of facilitators covering a wide range of topics that business owners need and have asked for, but we’ve also pulled various local resources together. We have time built-in for business owners to connect with experts from legal to insurance, lending to accounting and so much more.”Representatives from Entegra, Lady Bizness, the Sequoyah Fund, Stanberry Insurance, Smith & Morgan, P.A., Franklin Chamber of Commerce, Jackson County Chamber of Commerce and other area businesses will serve as guest speakers and offer resources for attendees.The breakout sessions include discussions on creating your own graphics to brand your business, social media, finances, taxes, the image you want your business to have, customer experience, time management, and how to sell your product/service.Registration is required at http://bit.ly/sccsmallbiz. Upon registering for the summit, attendees will be able to choose the breakout sessions that are most relevant to their business.Lunch will be provided.For more information about this or other free seminars offered by SCC’s Small Business Center, contact Henry at 828.339.4426 or [email protected]last_img read more

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Learn Secret Gutenberg Tips on September 14

first_imgHave you started using Gutenberg, the new WordPress editor currently in beta testing? Wondering if there are faster or easier ways to edit in Gutenberg?Or have you run into some issues, but haven’t figured out how to resolve the problems? Then you don’t want to miss this week’s Gutenberg YouTube Live talk and Q & A hosted by my friend Birgit Pauli-Haack on Friday, September 14, 2018. She’ll share all kinds of useful tips to make it easier for you to work with Gutenberg. The talk is free and open to any content creator, blogger, or do-it-yourself website owner.What You’ll LearnGutenberg keeps improving and adding features with each new release. But it also has several shortcuts and hidden features you might not know about. At the YouTube Live talk and Q & A, you’ll learn how to:Start a quote or ordered list quicklyApply code formatting around textDock the toolbar to the topAdjust the size of your editor window as well as many other Gutenberg editing tips. Have questions about Gutenberg? Ask away! There’s plenty of time in between tips to get your questions answered.Pauli-Haack will discuss what’s not quite working yet, and “gotchas” you want to avoid. In addition, you’ll learn about new features coming in Gutenberg 3.8, including Spotlight Mode and Full Screen Mode. What If You Haven’t Tried Gutenberg Yet But Still Want to Attend?I’ve got you covered! You’ll get more out of the talk if you’ve already used Gutenberg. And there are a couple ways to do that quickly.You can visit Test Gutenberg for a hands-on demo using Gutenberg. Add text, edit existing text, change colors, fonts, etc.Another option is to create a copy of your own WordPress site on a staging site, so you can test Gutenberg out with your own content, without making changes to your live site. According to the instructions in the post, it will take about 15 minutes to set up a staging site on Pantheon, for free. YouTube Live Talk DetailsThe Gutenberg YouTube Live and Q & A talk will be Friday, September 14, 2018 at 2:00pm Eastern Time. It’s free, no registration required. When I asked Pauli-Haack how long she expected it to last, she said about an hour.SummaryIf you want to:Learn shortcuts for using GutenbergAsk questions about something that you didn’t expect with GutenbergFind out about upcoming featuresjoin Pauli-Haack on Friday, September 14, 2018 at 2:00pm Eastern Time. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Click to print (Opens in new window)Like this:Like Loading…Relatedlast_img read more

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2010: Inzalo staff are ready!

first_img10 March 2010Inzalo Communications is not planning to miss the 2010 Fifa World Cup train. The Johannesburg-based company got out their football gear on 2 March to celebrate the start of the 100 days countdown with the rest of South Africa.Inzalo Communications getting into the South Africa 2010 spirit of things. (Photo: Inzalo Communications)The Inzalo team show off their readiness for the first Fifa World Cup on African soil. (Photo: Inzalo Communications)Football Fridays News Desklast_img

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Focus on Your Accomplishments During the Job Interview

first_imgPutting your best foot forward in the interview process is a critical aspect of a successful job search. But even more importantly, it can have a long-term impact on your loss prevention career in general. These impressions can have a lasting effect on how you are perceived as a professional as well as how you approach your career development plan. Whether the information serves as a reminder or a revelation, the most important objective should be to make a strong and lasting impression when exploring new career opportunities. Let’s take a closer look at how we should approach the interview:Focus on Your Accomplishments to Set Yourself ApartDuring the job interview, the person you’re speaking with wants to learn more about the person that they’re talking to in order to help determine whether or not they’ve found a good match. When asked about your experience, don’t simply reiterate your job descriptions. Talk about performance. Discuss the way that you responded to the different positions that you’ve held along your loss prevention career path, and the different things that you accomplished in those roles.Did you lead? Are you capable of creating something new and fresh? Can you develop programs? How much effort and success did you show at developing your subordinates? Are you capable of managing through change? Are you willing and able to show flexibility? How did you enhance results? Were you able to build business partnerships? A good interviewer wants to be able to see how you carry out your responsibilities so that they can then project you into the position that they are hoping to fill. Show the value that you can bring.- Sponsor – On the topic of strengths and weaknesses—always have both; and always attempt to turn the weakness into a positive. There is a reason that this is a popular question during the interview process; and while the answers are important, our response can reach well beyond what those specific strengths and weaknesses might be. Decision makers also want to know if you can be self-reflective—can you look yourself in the mirror and ask, “Where can I get better?” If this question is asked, the question that typically follows is “What are you doing about it?” Answer the second question before it is asked. Show the maturity and the resiliency to recognize your developmental needs, and the initiative to try to make personal improvement.A Winning Approach Starts with a Winning AttitudeA job interview provides a means to open a window into who we are—as a professional, as a leader, as a partner, and as a person. We are given precious minutes to summarize our value and our character; and make a positive and lasting impression on those having offered us the opportunity. This is a platform, and not a guarantee that others will see us for who we are. It is up to us to open the window and share the picture.But an interview is also something more. It is a search for a match, and a chance to take our skills and abilities to another level. It is a means to build upon our career, and find a home that not only meets our needs, but helps reveal our future. Unfortunately, it is also a skill that many take for granted. It’s simply not enough to be good at what we do. We also have to be able to share that information with others, and offer the best possible picture of who we are so that we continue to move forward down a successful and rewarding loss prevention career path.Check out loss prevention job opportunities at www.lpjobs.com.  Stay UpdatedGet critical information for loss prevention professionals, security and retail management delivered right to your inbox.  Sign up nowlast_img read more

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