Compounded pain relief creams not effective finds study

first_imgImage Credit: Africa Studio / Shutterstock By Dr. Ananya Mandal, MDFeb 6 2019A new study has shown that pain relief creams are no better than dummy or placebo creams when it comes to relieving pain. The study titled, “Compounded Topical Pain Creams to Treat Localized Chronic Pain: A Randomized Controlled Trial,” was published in the latest issue of the journal Annals of Internal Medicine. These pain relief creams are prescribed to be applied locally over localized pain sites for pain relief explain the researchers. They come at a relatively high cost but are not better than placebo creams they add. The experts add that there have been concerns regarding the safety of pain relievers and also side effects and abuse potential of opioid pain relievers. This has raised the prescriptions for these compounded pain relievers with no real data regarding their superior efficacy or safety. They have appealed to prescribers as well as users due to the perception of their low rates of side effects due to topical use.This study is a randomized controlled trial from the researchers at the Walter Reed National Military Medical Center. The team included 399 patients with either localized pain that was diagnosed to be due to nerve damage or neuropathic (total of 133 patients) or nociceptive pain or pain due to tissue injury (not nerves) (total of 133 patients) or mixed type of pain (133 patients). The groups were further divided into two and one half was given pain cream compounded specifically for their type of pain or a placebo or dummy cream. The drugs used in the compounded creams were FDA approved and routinely used for pain relief. This included agents such as non-steroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants (such as “ketoprofen, baclofen, cyclobenzaprine, and lidocaine”) for nociceptive pain and anticonvulsants and others (“ketamine, gabapentin, clonidine, and lidocaine”) for nerve pain. For the mixed pain treatment group compounds with “ketamine, gabapentin, diclofenac, baclofen, cyclobenzaprine, and lidocaine” were used.Related StoriesResearchers survey orthopedic providers to understand factors that drive opioid prescribing practicesStudy shows potential culprit behind LupusEngineered stem cells offer new treatment for metastatic bone cancerPain sensation was evaluated, a month after prescription of the creams. Results showed that there was no significant difference in improvement in pain symptoms with use of compounded pain creams compared to placebo creams. Around 28 percent participants in the placebo group and 36 percent participants in the pain cream group reported pain alleviation. This difference was not deemed to be significant enough for use of pain creams, write the researchers. Further, the compounded pain creams were most expensive compared to other creams, the authors add. Small benefits seen with these creams, they add, are due to the effects on the peripheral nervous system and not due to effects on the central nervous system.Senior study author Dr. Steven Cohen, a pain researcher at Walter Reed National Military Medical Center in Bethesda, Maryland, and Johns Hopkins Medicine in Baltimore in a statement said, “We know from other studies that some of the agents (lidocaine, non-steroidal anti-inflammatory drugs) may be effective for certain types of acute and chronic pain, so it is surprising that the difference here did not reach statistical significance in any of the pain types…This matters because compounded pain creams are much more expensive than prescribed (lidocaine, diclofenac) or over-the-counter (capsaicin) pain creams, but they didn’t provide meaningful benefit compared to placebo cream.” Authors conclude that these compounded pain relieving creams should not be prescribed routinely for treatment of pain.The study was funded and supported by the Centers for Rehabilitation Sciences Research, Defense Health Agency, U.S. Department of Defense.center_img Source:https://annals.org/aim/article-abstract/2724041/compounded-topical-pain-creams-treat-localized-chronic-pain-randomized-controlledlast_img read more

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Not drinking water may increase childrens consumption of sugary drinks

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Apr 22 2019Kids and young adults who drink no water throughout the day may consume twice the amount of calories from sugary drinks than those who drink water, according to Penn State researchers.Asher Rosinger, assistant professor of biobehavioral health and director of the Water, Health, and Nutrition Lab, said the results — published today (Apr. 22) in the Journal of the American Medical Association Pediatrics– underscore the importance of children having free access to clean water.”Kids should consume water every single day, and the first beverage option for kids should be water,” Rosinger said. “Because if they’re not drinking water, they’re probably going to replace it with other beverages, like sugar sweetened beverages, that are less healthy and have more calories.”According to Rosinger, sugar-sweetened beverages includes soda, sweetened fruit juices, sports drinks, energy drinks, and sweetened tea and coffee drinks. They do not include 100 percent fruit juices, drinks sweetened with zero-calorie sweeteners, or drinks that are sweetened by the consumer, like coffee or tea brewed at home.Rosinger added that while other research has shown an overall decline in the consumption of sugar-sweetened beverages, there are still subpopulations of kids in the U.S. who are more likely to consume sugary drinks. He and his collaborators wanted to better understand how many kids drink water on a given day, how many do not, and how their caloric intake from sugar-sweetened beverages differ.The researchers used data from the National Health and Nutrition Examination Survey, a nationally representative data set that includes information on 8,400 children between the ages of two and 19. Data included information about the children’s water and sugar-sweetened beverage consumption, as well as calories from sugary drinks and the percent of total calories coming from sugary drinks.Related StoriesGuidelines to help children develop healthy habits early in lifeResearch reveals genetic cause of deadly digestive disease in childrenRepurposing a heart drug could increase survival rate of children with ependymomaAfter analyzing the data, the researchers found that on a given day, about 20 percent of children reported drinking no water. Additionally, those children consumed almost twice as many calories from sugar-sweetened beverages — about 200 calories total — than children who did drink water.Rosinger said that while an extra 200 calories may not seem like a lot, it can add up quickly if someone is drinking sugar-sweetened beverages on a regular basis.”What you have to remember is that an extra 3,500 calories equals one pound of weight gain,” Rosinger said. “So if you’re not compensating for those extra calories, then over a month, you can potentially gain a pound. Over several months, that could add up.”Additionally, the researchers found that while the United States Department of Agriculture recommends that no more than 10 percent of a person’s daily calories should come from added sugars, the children who did not drink any water on a given day tended to exceed this limit from sugary drinks.Rosinger said that while urging people to drink water is important, there are many reasons why kids may not drink any or enough water during the day.”It’s important to note that in parts of the U.S., some people may not trust their water due to lead or other contamination,” Rosinger said. “Water insecurity is a growing problem in the U.S., so we need to keep that in mind as important context, especially when it comes to parents who may be giving their kids soda or juice because they distrust the water.”In the future, Rosinger wants to explore possible interventions to help boost water intake in children.Hilary Bethancourt, a postdoctoral scholar in the Water, Health, and Nutrition Lab in biobehavioral health, and Lori A. Francis, associate professor of biobehavioral health, collaborated on this research. Source:https://news.psu.edu/story/569568/2019/04/22/research/not-drinking-water-may-boost-kids-consumption-sugary-beverageslast_img read more

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Withdraw Dam Safety Bill Palaniswami tells PM Modi

first_imgSHARE COMMENT Our Bureau Tamil Nadu Chief Minister Edappadi K Palaniswami has urged Prime Minister Narendra Modi not to go ahead with the legislation on dam safety till the State’s genuine concerns are addressed and a consensus is evolved among all States. In a letter to Modi, the Chief Minister also urged him to instruct the Ministry of Water Resources, River Development and Ganga Rejuvenation to withdraw the Dam Safety Bill, 2018 introduced in the Lok Sabha on December 12. Earlier letterIn a letter written on June 15, Palaniswami had urged Modi not to legislate an Act on Dam Safety till all the States are consulted and consensus is evolved. The Resolution passed by the Tamil Nadu Legislative Assembly on June 6, expressing concerns of the people of Tamil Nadu on the proposed Dam Safety Bill was also sent to the Centre. However, a Bill has been introduced in the Lok Sabha without considering views/comments of the State governments, Palaniswami said. The Bill specifies that where the specified dam in one State is owned by another State, then the National Dam Safety Authority would act as the State Dam Safety Organisation for that particular dam. This implies that the dam owning State will have no rights over safety and maintenance of the dam located in another State. Dams in Kerala Mullaperiyar, Parambikulam, Thunakkadavu and Peruvaripallam dams are owned, operated and maintained by the Tamil Nadu government by virtue of Inter State Agreements but are located in neighbouring Kerala. Further, the Constitution Bench of the Supreme Court upheld the rights of Tamil Nadu on the Mullaperiyar dam in a ruling on May 7, 2014. To deny Tamil Nadu the right to be the Dam Safety Authority to these four dams and vesting the powers to the National Dam Safety Authority will tantamount to encroaching on the rights of Tamil Nadu, which is unconstitutional. It is also a violation of the federal principles enshrined in the Constitution, the letter said. “I request, that the clause should be suitably amended to ensure that the Dam Safety Organisation of a State should have jurisdiction over the dams owned, controlled, operated and maintained by it even though they are located in another State,” it added. SHARE SHARE EMAIL December 15, 2018 Published on COMMENTSlast_img read more

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Violence erupts in University college campus in Thiruvananthapuram student stabbed

first_imgViolence erupts in University college campus in Thiruvananthapuram; student stabbedA case has been registered against six students, including college union leaders of the Students Federation of India (SFI), police said.advertisement Press Trust of India ThiruvananthapuramJuly 12, 2019UPDATED: July 12, 2019 23:37 IST Students of University College protested outside the college after a 3rd year student got stabbed in a clash. (Photo: ANI)Violence erupted in the University college campus here with a student being stabbed Friday morning, police said. Akhil, a third-year Political Science student, who was sitting under a tree along with friends, was stabbed on the chest.The injured student was rushed to the Trivandrum medical college hospital. Hospital sources said he would have to undergo surgery due to internal bleeding, but that his condition was stable.Three other students were also injured in the attack. Angry students demanded immediate arrest of the accused. They said Akhil was singing a song, which irked the SFI students.A case has been registered against six students, including college union leaders of the Students Federation of India (SFI), police said.”We have also registered a case against around 20 unidentified students in connection with the incident,” an investigating officer told PTI.The incident was a sequel to a dispute between two groups of students belonging to the pro-CPI(M) students wing.Soon after the incident, angry students squatted on the road in front of the college gate and raised slogans, demanding justice.Akhil also belongs to the SFI. “We have searched the campus for the accused, but they were not there. We will conduct further searches at various other places tonight,” police said.Opposition Leader Ramesh Chennithala lashed out at the students’ wing of the CPI(M) and said the latest attack on the student showed the “terror face” of SFI.”The SFI, which never allows any other student organisation to work inside the University College, has now turned towards its own workers.This exposes the fascist attitude of SFI,” he said in a release.The Left government has asked the Education Department to submit a report on the issue.Meanwhile, BJP state President P S Sreedharan Pillai also attacked the ruling CPI(M) and its student organisation and said no action has taken against such attacks, despite complaints by students.University College, Thiruvananthapuram is one of the oldest and most prestigious institutions of higher education in India, established in 1866 to impart English education to the common folk of erstwhile Travancore by Sri Ayilyam Thirunal Rama Varma Maharaja.Also Read | West Bengal: TMC leader Sofiul Hasan shot dead in MurshidabadAlso Watch | BJP is using money power: Abhishek Manu Singhvi on Karnataka crisisFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan Nextlast_img read more

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